Users of Zepbound or Mounjaro had lower blood pressure in the study

A study of the weight loss drug tirzepatide showed that people who took it had significantly lower blood pressure after 36 weeks of taking the drug.

Tirzepatide, manufactured by Eli Lilly, is used to treat type 2 diabetes under the brand name Mounjaro and to treat obesity under the brand name Zepbound. It is the latest in a new class of weight-loss drugs, and its main competitor is semaglutide, made by Novo Nordisk and sold as Ozempic for diabetes and as Wegovy for weight loss. For both drugs, researchers examined whether they had additional effects beyond weight loss.

The blood pressure studyThe study, supported by Eli Lilly and published Monday in the journal Hypertension, was part of a larger effort to assess the effects of tirzepatide on weight loss. Researchers had already found that people who took the drug had lower blood pressure when measured in a doctor’s office. The new study used stricter criteria: Did the participants taking the drug have lower pressure when measured with a 24-hour monitor?

They did. Those who took the drug had systolic blood pressure — the pressure on blood vessels when the heart contracts — that was 7.4 to 10.0 milligrams of mercury lower than that of participants who took a placebo. Systolic pressure is believed to be an accurate predictor of heart disease risk.

The reduction in blood pressure, said Dr. According to Dr. James de Lemos, a cardiologist at the University of Texas Southwestern Medical Center and lead author of the study, this is roughly what would be expected with a full dose of a blood pressure medication. Therefore, he said, the drug may be useful for people trying to control their blood pressure and reduce their risk of heart attack and stroke (although the study does not suggest replacing other blood pressure medications with tirzepatide).

But it’s not possible to distinguish the drug’s effect on blood pressure, if any, from the known effect of weight loss on…, he noted.

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