Single-molecular tests reveal the power potential of synthetic molecular motors TOU

Single-molecular tests reveal the power potential of synthetic molecular motors


Single-molecular tests reveal the power potential of synthetic molecular motors

Nanoscale (2021). DOI: 10.1039 / D1NR02296B “width =” 800 “height =” 370 “/>

The figure shows the magnetic tweezers system for detecting the (left) force of a single molecule motor and the two recorded paths showing the fast step motion of the motor (right, 1.5 pN against the opposite force). The top and bottom panel on the right show the recorded individual hierarchical phenomena of the molecular motor with fluctuations in the typical operating speed of single-molecular tests. A single two-legged nanomotor with a long path is composed of several short single-stranded DNA molecules under an arc magnetic field. The motor moves automatically by fueling a short single-stranded DNA with the help of a protein enzyme. The movement of the molecular motor is against the backward force applied to the pedal, which allows to measure the load-resistance movement and key output of the motor. debt: Nano scale (2021) DOI: 10.1039 / D1NR02296B

Physicians at the National University of Singapore have demonstrated that a single molecule created by man can express a force similar to the naturally occurring force that supplies energy to human muscles. Their results have been released Nano scale.

Molecular motors are a class of machines with nanoscale dimensions that are essential agents for the movement of organisms. They use various energy sources in the body to create mechanical motion. An important characteristic is the force generated by a motor during its self-propelled motion. This key generating ability allows the molecule to deliver mechanical work to the motor and is a measure of its energy transfer capability, which affects its utility in potential applications.

The measurement of energy generated by naturally occurring molecular motors, usually made up of proteins, was achieved two decades ago. However, measurements such as man-made molecular motors with DNA (deoxyribonucleic acid) remain challenging. Research collaboration between NS Physics Associate Professor Jizong Wang’s Molecular Motors Laboratory and Professor Ji Yan’s Laboratory of Single-Molecular Biophysics was able to discover the power generated by the moving DNA molecular motor.

Synthetic motors are difficult to detect in keys generated by a single molecular motor in motion because they operate on small and often smooth tracks (e.g. double-stranded DNA). The smooth tracks are not fixed in position and are curled into a circular shape. This affects the movement of the synthetic motor. The research team overcame this difficulty by designing and implementing parallel single-molecule experiments that kept the tracks at the nanoscale level while at the same time detecting small forces generated by the moving molecular motor. Using a magnetic tweezers technique, they first assembled a synthetic molecular motor and its path under a paramagnetic bead (a tool for isolating living molecules). They then converted the arc magnetic beads into a key detection system (see picture).

The research team successfully applied their method to an autonomous DNA molecule motor (previously developed by Professor Wang’s laboratory). This two-legged molecular motor, with a length of about 16 nm between each stroke, delivers a maximum power output of 2 to 3 pN. This measured force output is close to the naturally occurring molecular motors that drive human muscles, which means that chemical energy can be reasonably efficiently converted into mechanical motion.

Professor Wang said, “This study is paving the way for the development of applications related to translational synthetic molecular motors, examples of which include molecular robots and the activation of artificial muscles.

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                                        Physicists develop self-propelled molecular motors that run on tracks
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                                                                                            <strong>More info:</strong>
                                            Xinpeng Hu et al, single-molecular machine study of an autonomous synthetic translation molecular machine beyond bridge-burning design, <i>Nano scale</i> (2021)  <a data-doi="1" href="" target="_blank" rel="noopener">DOI: 10.1039 / D1NR02296B</a>


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                                            Presented by the National University of Singapore
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                                             <strong>Quote</strong>: Single-molecule tests reveal the potential of synthetic molecular motors (2022, April 13)

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